Welcome to January 2023 and volume 24 of Pediatric Critical Care Medicine (PCCM). It is a great start to the year. I must draw your attention to my three Editor’s Choice articles: a national Dutch PICU registry study of adverse events in seven units (1); an American Heart Association Get With the Guidelines-Resuscitation (GWTG-R) registry study of in-hospital cardiac arrest (IHCA) in adults who are managed in 17 PICUs in the United States (2); and, a retrospective study of SARS-CoV2 infection in nine PICUs in the United States (3). All three of these reports have accompanying editorials (4–6). WHAT IS THE ROLE OF ADVERSE EVENTS IN MORTALITY AMONG PATIENTS STRATIFIED AS LOW-RISK AT TIME OF PICU ADMISSION? Verlaat CW, Zegers M, Klein R, et al; PICE registry (Pediatric Intensive Care Evaluation)/SKIC (Dutch Collaborative PICU Research Network): Adverse Events in Pediatric Critical Care Nonsurvivors With a Low Predicted Mortality Risk: A Multicenter Case Control Study (1). Our reading starts with an analysis of the national Dutch PICU registry data which contains over 53,000 admissions (2006−2017) to seven PICUs (1). The authors have selected 419 patients for a case-control comparison of whether adverse events (e.g., drug or fluid related, or hospital acquired infection) were observed in low-risk of mortality patients, and the statistical contribution to mortality. The accompanying editorial is very important (4). There are useful insights into the history of severity scoring systems in our field, the unique at-risk PICU population of “underlying complex chronic conditions,” and a call to follow a new path to data sharing. An example of the relevance of these two contributions is immediately obvious if you also read the Brief Report from the Virtual Pediatric Systems Database on variable identification of children with medical complexity in US PICUs (7). ADULT SURVIVORS OF LONG-STANDING, CHILDHOOD-ONSET, ILLNESS: WHAT IS THE PREVALENCE OF PICU MANAGEMENT AFTER IHCA? O’Halloran AJ, Grossestreuer AV, Balaji L, et al: Characteristics and Outcomes of Cardiac Arrest in Adult Patients Admitted to Pediatric Services: A Descriptive Analysis of the American Heart Association’s Get With the Guidelines-Resuscitation Data (2). In some large pediatric hospitals, their work now consistently includes specialist care for adult survivors of long-standing, childhood-onset, illness and disease. My second Editor’s Choice is a GWTG-R registry study of IHCA outcomes and quality-of-care in almost 500 patients older than 18 years of age managed in any of 17 centers, 2000−2018 (2). The accompanying editorial provides a useful cardiology perspective, as well as the imprimatur of writers who also work at a center incorporating care for exactly the group of patients being reported in the GWTG-R study (5). WHAT HAVE WE LEARNT IN THE PICU FROM THE EVOLUTION OF SARS-CoV-2 VARIANTS? Ross CE, Burns JB, Grossestreuer AV, et al: Trends in Disease Severity Among Critically Ill Children With Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Multicenter Cohort Study in the United States (3). My third highlighted article is from nine PICUs in the United States in which COVID-19 patients from two 3-week periods were compared: that is, March 14th to April 3rd (2020) during the Original (D614) form versus January 1st to 21st (2022) during the Omicron (B.1.1.529) variant (3). We learn about the time course, outcomes, and interventions in 267 patients. Our editorialists also update their Special Article from PCCM July 2021–Coronavirus Disease 2019: A pandemic Spawning an Infodemic (8)–and now give an added dialogue on public health (6). “PCCM CONNECTIONS” FOR READERS The reading theme for our subscribers and trainees is a focus on literature reviews: we have four this month. The first is a systematic review about discharge directly home from the PICU using five studies describing prevalence in large datasets from the US, United Kingdom, and Australia and New Zealand (9). The same research group carrying out the review also report their experience in a single center in Canada in this month’s issue (10). The second systematic review is about antibiotic stewardship programs (11), which picks up the same theme running through PCCM on antimicrobials for ventilator-associated infection (12), bronchiolitis (13), and cardiac intensive care (14). The third systematic review is about prognostic and goals-of-care communications (15). From my point of view, it has a very interesting background. In the September 2021 issue of PCCM we featured a survey of 100 parents and PICU physicians and their conversations about prognosis (16). Our editorialists explored the implications of that research and provided a four-step plan toward improved communication within the multidisciplinary PICU team (17). Now, guess who has carried out the systematic review on the subject? A team combining our previous authors and editorialists! Please go back and read all the content together. Finally, we have the topic of anemia from blood sampling during PICU admission. We know from an online survey of 217 pediatric intensivists from around the world that there is considerable uncertainty about how to manage anemia at PICU discharge (18). We also know from a prospective, single-center cohort study in Canada (published in PCCM, June 2022) that there remains a major impact of diagnostic blood sampling on anemia during PICU admission (19). The authors of the cohort study currently provide us with a scoping review on strategies to reduce blood loss anemia from blood sampling (20). Once again, take time to refresh your memory on all this content.